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KMID : 0043320010240060541
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Archives of Pharmacal Research
2001 Volume.24 No. 6 p.541 ~ p.545
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Anti-inflammatory, Analgesic and Antipyretic Activities of Loxo-profen Sodium Given Intramuscularly in Animals
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Hyun JE
Li DW/Lee EB/Jeong CS
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Abstract
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The evaluation of the anti-inflammatory, analgesic and antipyretic activities of loxoprofen sodium given in intramuscular route was investigated as compared to oral application in rats and mice. The intramuscular ED50 values of loxoprofen sodium in carrageenan edema and vascular permeability tests are 1.15 and 7.8 mg/kg, respectivelyl which represent more potent than in case of oral application. Its therapeutic effects in adjuvant arthritis were shvn at 6mg/kg I.m. and 3mg/kg p.o. Analgesic effect was shown to be more potent as given intramuscularly. Similar potency of antipyretic effects was shown in both administration routes. Considerably weak gastric damages were observed in intramuscu far application.
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